CYBB and chronic granulomatous disease: More than 700 different mutations responsible for CGD have been identified (31), and we found 6 new mutations, 4 in CYBB and 2 in NCF1. Although we did not perform functional experiment, the clinical presentation, compromised granulocyte function with evidence of DHR assay and non-synonymous mutations in CGD-related genes were convicing evidence for causative mutations.