There were no differences in gene expression of NLRP3, PYCARD, or CASP1 in monocytes from people with gout which was consistent with our observations that pre-incubation of monocytes with uric acid did not influence gene expression of IL1B or the antioxidant enzymes SOD2 or TXNRD1. This suggests that susceptibility to gout attacks is not due to an inherent hypersensitivity in the leukocytes of these patients nor is there a compensatory increase in expression of SOD2 that might reflect increased oxidative stress. This evidence concerns the gene NLRP3 and gout.