IL10 and Chronic colitis: In support of our actual results, we demonstrated previously that peroral MDR Psae application to conventionally colonized IL-10−/− mice suffering from chronic colitis aggravated the outcome of the underlying intestinal immunopathological disease (16), again not only on the local (i.e., intestinal) level, but also beyond (i.e., in extra-intestinal and even systemic compartments).