Similarly, miR-522 and miR203, which are up-regulated in synovial fibroblasts of RA patients, respectively, increased the expression of TNF-α and IL-1β via targeting SOCS3 (29) and of IL-6 by targeting inhibitors of the NF-κB pathway, although these could not be further identified (30). The gene discussed is IL6; the disease is rheumatoid arthritis.