Based on the Oncomine database, we found that LAYN, compared to normal tissues, was highly expressed in breast, colorectal, gastric, kidney, pancreatic cancers, and lymphoma, while some data sets showed that LAYN has a lower level of expression in bladder, breast, colorectal, head and neck, lung, ovarian, and prostate cancers (Figure 1A). Here, LAYN is linked to Familial prostate cancer.