LAYN and colorectal cancer: Two cohorts (GSE17536, GSE14333) (30, 31) included 177 samples and 226 samples at different stages of colorectal cancer and showed that high LAYN expression was marginally associated with poorer prognosis (OS HR = 1.50, 95% CI = 0.98 to 2.29, Cox P = 0.06; DSS HR = 1.84, 95% CI=1.15 to 2.97, Cox P = 0.012; DFS HR = 2.32, 95% CI=1.27 to 4.25, Cox P = 0.006; DFS HR = 1.72, 95% CI = 1.21 to 2.46, Cox P = 0.003) (Figures 2A–D).