Examples of T2DM risk genetic loci, which are also associated with rare recessive disorders, are LIPC (Hepatic lipase deficiency), PDX1 (Pancreatic agedness 1), ENPP1 (Hypophosphatemic rickets, also associated with obesity), WFS1 (Wolfram syndrome 1), and SLC2A2 (Fanconi-Bickel syndrome). The gene discussed is WFS1; the disease is Obesity.