Furthermore, genetic variants thought to be implicated in BD such as BDNF, MTHFR, GNAS, and CACNA1C/D, have been hypothesized to overlap between BD and CVD, conferring risk of mood disorders in addition to risk of hypertension, type 2 diabetes, obesity, and dyslipidemia (46, 58). This evidence concerns the gene GNAS and obesity due to melanocortin 4 receptor deficiency.