In several cancer cell lines, including glioma (Inoue et al., 2007b), neck squamous cell carcinoma (Lai et al., 2013), non-small cell lung cancer (Grbesa et al., 2015), breast cancer (McGlynn et al., 2014), prostate cancer (Kim et al., 2011), and HCC (Chen et al., 2013), SIRT2 gene is found downregulated or deleted. The gene discussed is SIRT2; the disease is cancer.