SIRT4 and thyroid gland carcinoma: Although few studies have analyzed the role of SIRT4 in tumorigenesis to date, low expression of SIRT4 is reported in many cancers such as bladder, breast, colon, stomach, ovarian, and thyroid cancer, and correlates with a worse prognosis (Jeong et al., 2013; Huang and Zhu, 2018).