As outlined above, in CF TMEM16A membrane expression is compromised (Ruffin et al., 2013; Benedetto et al., 2017), Cl− secretion through CFTR is missing (Namkung et al., 2010a; Billet and Hanrahan, 2013; Benedetto et al., 2017; Lerias et al., 2018), and most TMEM16A is expressed in mucus secreting cells (Benedetto et al., 2019). Here, CFTR is linked to cystic fibrosis.