LRRK2 and Parkinson disease: Based on our comprehensive analysis of the common LRRK2 variants, we concluded that A419V, R1398H, R1441C/G/H, R1628P, G2019S, and G2385R were associated with greater PD risk (p: 0.001, 0.0004, < 0.00001, < 0.00001, and < 0.00001, respectively), while R1398H was associated with decreased PD risk (< 0.00001; Figure 2).