Among the LRRK2 variants which were of statistical significance in previous meta-analyses, the most frequently-occurring LRRK2 variants in PD patients were, in descending order, R1398H, G2385R, R1628P, and A419V, which had MAF ranging from 0.094 to 0.012 in East Asian populations (Figure 2; Supplementary Table 3). The gene discussed is LRRK2; the disease is Parkinson disease.