For instance, a murine model of MS-the experimental autoimmune encephalomyelitis (EAE; Constantinescu et al. (2011))-showed a reduction in GJ plaques composed by both Cx32 or Cx47 in oligodendrocytes within and around lesions but also in the normal appearing white matter (Markoullis et al., 2012). This evidence concerns the gene GJB1 and myeloid sarcoma.