GJC2 and Pelizaeus-Merzbacher-like disease: Mutations in Cx47 have been found in patients with the central hypomyelinating disorder known as Pelizaeus-Merzbacher-like disease (also known as hypomyelinating leukodystrophy 2) and the hereditary spastic paraplegia (Sargiannidou et al., 2010; Tress et al., 2011; Cotrina and Nedergaard, 2012).