GJC2 and leukodystrophy: Supporting the role of oligodendrocyte connexins in myelination, ablation of Cx32 and Cx47 generates a phenotype of hypomyelinated leukodystrophy characterized by alterations in gene expression of key enzymes required for the synthesis of myelin lipids, as well as increased expression of genes linked with leukotrienes/prostaglandins synthesis and chemokines/cytokines interactions and signaling pathways (Wasseff and Scherer, 2015).