Finally, high expression of the basic-loop-helix transcription factor NeuroD1 is associated with poor prognosis in patients with neuroblastoma and NeuroD1 was found to be highly expressed in hyperplastic regions consisting of neuroblasts in the celiac sympathetic ganglion of 2 weeks old Th-MycN mice developing neuroblastoma (Huang et al., 2011). The gene discussed is NEUROD1; the disease is neuroblastoma.