Some of the GWAS-defined neuroblastoma susceptibility genes which include CASC15, BRCA1-associated RING domain protein 1 (BARD1), LMO1, DUSP12, DDX4, IL31RA, HSD17B12, HACE1, LIN28B, and NEFL have been shown to display oncogenic or tumor suppressive functions in established disease (Maris et al., 2008; Capasso et al., 2009, 2013, 2014; Diskin et al., 2009; Wang et al., 2011; Bosse et al., 2012; Pandey et al., 2014; Oldridge et al., 2015; Russell et al., 2015). The gene discussed is CASC15; the disease is neuroblastoma.