RHO and neuroblastoma: Other less frequently detected mutations in primary neuroblastomas are often in genes in which the protein is involved in the regulation of signal transduction pathways as exemplified by detection of genetic lesions in the MAPK signaling cascade in 3%–5% of primary neuroblastomas (Pugh et al., 2013) and in 28% of genes responsible for correct neuritogenesis, many in the Rho family of genes (Molenaar et al., 2012; Dyberg et al., 2017).