Germline loss-of-function mutations of the paired-like homeobox 2B (PHOX2B) gene has also been reported in familial neuroblastoma as well as in approximately 4% of high-risk spontaneous neuroblastoma cases (Mossé et al., 2008; Cheung et al., 2012; Pugh et al., 2013). Here, PHOX2B is linked to neuroblastoma.