TH and neuroblastoma: Gain-of-function mutation of ALKF1174F can induce neuroblastoma in mice if ALKF1174F is under control of the dopamine-β-hydroxylase (Dbh) promoter but require high Mycn expression in order to develop neuroblastoma when ALKF1174F expression is controlled by the Th promoter in both mice and zebrafish (Weiss et al., 1997; Berry et al., 2012; Zhu et al., 2012).