However, the fact that the prediction of cognitive decline by APOE e4 status was so much larger than that of the Alzheimer’s PGS, which itself contains the effect of (SNPs in linkage disequilibrium with) APOE e4, suggested that the effects of the other SNPs—less significantly or not significantly related to cognitive decline—included in the PGS were overpowering the APOE e4-linked signal. This evidence concerns the gene APOE and Mental deterioration.