To validate our proteomic screen, we performed co-immunoprecipitation experiments in both ARP-1 and OPM-1, two MM cell lines, and confirmed the interaction between stably expressed FLAG-IKZF1 and IKZF3 and endogenous RUNX1 and RUNX3 (Fig. 1d). Here, IKZF1 is linked to Miyoshi myopathy.