CD274 and neoplasm: In recent years, cancer immunotherapy has focused on the development of a new generation of immunotherapy agents, which specifically block the interplay between tumor cells and the immune system, known as immune checkpoint inhibitors, of which the PD1/PD-L1 axis is but just one target [4, 5]; other targets of interest include cytotoxic T lymphocyte-associated protein 4, lymphocyte-activation gene 3, and killer-cell immunoglobulin-like receptor [4–7].