Although most DNA demethylation, which we think occurred in a passive manner as a consequence of tumor progression, did not increase gene expression, we identified a few genes that were transcriptionally upregulated with CpG locus demethylation such as IGF2BP3. IGF2BP3 is an RNA binding protein that binds to the 5′-untranslated region of IGF-2 mRNA and activates its translation26. Here, IGF2 is linked to neoplasm.