Upon EZH2 knockdown, fold change in the target gene expression for GPNMB, CoL5A1, POMT2, PMEPA1, VGLL4 and SUMF1 was found to be 1.3, 2.8, 2.2, 2, 1.7 and 1.8, respectively in MCF-7 breast carcinoma cells as detected by qPCR (Fig. 3H). This evidence concerns the gene COL5A1 and breast carcinoma.