However, whereas LC3-A was significantly increased in both highly affected areas (medulla oblongata and pons) and cell populations with a lower degree of lesion (cerebellar Purkinje cells), LC3-B seemed to be slightly increased in most of the areas analysed in scrapie brains but was significantly upregulated only in two of the less affected areas, cerebellum and basal ganglia. This evidence concerns the gene MAP1LC3A and scrapie.