MAP1LC3B and scrapie: However, whereas LC3-A was significantly increased in both highly affected areas (medulla oblongata and pons) and cell populations with a lower degree of lesion (cerebellar Purkinje cells), LC3-B seemed to be slightly increased in most of the areas analysed in scrapie brains but was significantly upregulated only in two of the less affected areas, cerebellum and basal ganglia.