We emphasize the implication of lymphatic vessels in view of PTECs and pro-inflammatory macrophage activation under lipotoxic condition and that dysfunctional lymphatic proliferation can be attenuated by reduced lipotoxicity through PPARα-AMPK pathway, suggesting its potential as a target for lipid-related diseases, including diabetes, especially type 2 diabetes, and HFD-induced renal damage. This evidence concerns the gene PRKAA1 and diabetes mellitus.