This pro-inflammatory condition is ascribable to systemic hyperglycemia and intrarenal lipotoxicity that promote increased production of TGF-β and recruitment of macrophages, which coordinately augment the production of vascular endothelial growth factor (VEGF), possibly triggering a cytokine cascade to induce lymphangiogenesis in renal cells5. This evidence concerns the gene VEGFA and Hyperglycemia.