SPOCD1 protein product belongs to TFIIS family transcription factors, SPOCD1 plays important functions in mediating inhibition of cancer cell proliferation63 and inducting cell apoptosis in breast, lung, gastric and pancreatic cancer cell lines through activation of p5364 and TGF-β signaling pathways65,66, the biological process involved by these genes ultimately plays a crucial role in the regulation of host inflammatory response. The gene discussed is TGFB1; the disease is cancer.