SPP1 and bacterial infectious disease: Importantly, some immune-related genes were also found significantly differentially expressed and enriched in these bacterial infection associated pathways, such as TLR8, LBP and SPP1 in toll-like receptor signaling pathway, HSP70 and CD8A in antigen processing and presentation, CXCL9, CXCL10, CCR5 and CCL17 in chemokine signaling pathway.