AAV8-TBG-Cre Ctnnb1ex3/+ mice develop hepatomegaly within 2 weeks post-induction, and develop a liver failure phenotype which was completely suppressed through deletion of Bcl9/9l, where mice were aged up to 140 days before being euthanised (Fig. 7a and Supplementary Figure 14e). This evidence concerns the gene BCL9 and Hepatic failure.