In this study, by integrating multi-omic profiles, we comprehensively characterized the genomic alterations of 73 HAMP genes (Supplementary Data 1)1, including 18 HAT genes, 43 BRD-containing genes (including 6 HATs that also contain BRDs), and 18 HDAC genes, across the whole TCGA data cohort (n > 10,000, including samples of 33 cancer types from 27 primary sites, Supplementary Data 2). The gene discussed is TMPRSS11D; the disease is cancer.