EP300 and cancer: Although EP300 and CREBBP were widely mutated in multiple cancer types (7 and 4 cancer types, respectively; Fig. 3b), the recurrent mutations of HAMPs were largely cancer type-specific (Fig. 4b): 17 of 34 (50%) HAMPs with recurrent mutations were only observed in one cancer type and no recurrent mutation of HAMPs was found in more than 7 cancer types.