This is consistent with results from the human colorectal cancer cell line COLO320 whose APC truncation is ApcMin-like and atypically short for human cancers59 and which exhibit 2–3 fold higher levels of β-catenin-dependent transcription compared to typical colorectal cancer cells60 whose longer APC truncations retain moderate function in downregulating β-catenin. Here, APC is linked to colorectal cancer.