In the future, examining the PGC-1α/SOD2/CYCS, NRF2/GCLC/NQO1, and NFYA/ HSPA5 pathways in SCA17 mice treated with specific constituents of SG-Tang is warranted to uncover the underlying mechanisms. The gene discussed is GCLC; the disease is spinocerebellar ataxia type 17.