Nevertheless, the shift in the aggregation state of amyloid between APP/PSEN1 and APP/PSEN1/APOEnull has been reported in other studies (Bales et al, 1997; Irizarry et al, 2000a) and essentially reproduces the morphological difference between β-pleated sheet deposits (labeled with Thioflavin-S) mostly observed in AD patients and diffuse plaques detected in non-demented individuals (Dickson, 1997; Urbanc et al, 2002). The gene discussed is APP; the disease is Alzheimer disease.