APOE and Alzheimer disease: Although those findings clearly emphasize the pivotal role of APOE in AD neuropathological changes, the field is still divided as to whether or not clinical benefit could be achieved by reducing the levels of APOE (Koldamova et al, 2005; Bien-Ly et al, 2012; Liao et al, 2014; Lane-Donovan et al, 2016; Zheng et al, 2017).