While the density of synapsin and PSD95 puncta was dramatically reduced in the vicinity of amyloid deposits in APP/PSEN1 mice (by about 30%, as we have previously reported [Koffie et al, 2009; Kay et al, 2013]), no such reduction of pre- or post-synaptic elements was detected in APP/PSEN1/APOEnull mice. Here, APP is linked to amyloidosis.