In the case of Ad5-mSPC-Cre, the Cre recombinase is expressed from the mouse surfactant protein C (SPC; also known as Sftpc) promoter, allowing more restricted expression of KrasG12D to alveolar type II cells and inducing the development of AAH/adenoma (Sutherland et al., 2014). This evidence concerns the gene NLRP1 and adenoma.