Robinow syndrome (Box 1), which frequently includes cleft palate, is associated with mutations in WNT5A (Person et al., 2010), along with mutations in the co-receptor gene receptor tyrosine kinase-like orphan receptor 2 (ROR2) (Afzal et al., 2000; van Bokhoven et al., 2000) and the signal transducer DVL1 (Bunn et al., 2015; White et al., 2015), indicating the importance of a non-canonical WNT5A/ROR2/DVL1 signaling cascade in human palatogenesis. The gene discussed is DVL1; the disease is cleft palate.