LRP6 and orofacial cleft: By contrast, frameshift, nonsense and missense mutations in the WNT co-receptor gene LRP6 have been associated with orofacial clefts and tooth agenesis (Basha et al., 2018; Ockeloen et al., 2016), suggesting that deficient LRP6-mediated canonical WNT signaling has a crucial role in CLP pathogenesis.