In the present study, the downregulation of SFRP2 and overexpression of CMKLR, COL8A, NRK, and SYTL2 reported herein revealed enhanced migratory and invasive potential abilities from DMSCs to other cells in psoriasis, which may be beneficial to the immunomodulatory properties of MSCs. This evidence concerns the gene SYTL2 and psoriasis.