Compared with placebo, mTOR inhibitors significantly reduced tumor volume in both AML (RR = 24.69, 95% CI = 3.51,173.41, P = 0.001) and SEGA (RR = 27.85, 95% CI = 1.74,444.82, P = 0.02). This evidence concerns the gene MTOR and acute myeloid leukemia.