Moreover, in human multiple myeloma (MM) cell lines including RPMI 8266, U266, and XG7, Cx43–gap junctions formed between human MSCs and MM cells reduced bortezomib-induced RCD, such as apoptosis and/or necroptosis, with the function reversible by gap junction inhibitors [66]. This evidence concerns the gene GJA1 and Miyoshi myopathy.