Factors including TP53 status, MGMT promoter status, Chr7gain/Chr10loss, and IDH1/2 status were associated with the OS of GBM patients; interestingly, a Cox regression analysis including the above factors plus AEI showed that the editing index is indeed an independent prognostic factor for GBM OS in male patients, thereby demonstrating that male patients with a high AEI have a significantly decreased risk of death (HR, 0.278; p = 0.0217). This evidence concerns the gene TP53 and glioblastoma.