Herein, we demonstrated that in de novo GBM, ADAR levels were profoundly altered with a strong decrease of ADAR2 and ADAR3, both of which are significantly connected (even if with opposite trends) with the REI (editing at recoding sites) at least in normal brain and ADAR1 correlating with the loss of AEI. The gene discussed is ADAR; the disease is glioblastoma.