INO-2 GBM subgroup is characterized by genes belonging to the p53-pathway (such as MDM2/4 and CCND1) and by the upregulation of important genes such as PDGFRA, IGF2, and VEGFA and genes coding for nucleosome proteins (Fig. 9 and Additional file 7: Table S6). This evidence concerns the gene VEGFA and glioblastoma.