The GRIK2 Q/R, Y/C, and GABRA3 I/M sites emerged as sites with a remarkable editing decrease in GBM (with an editing drop ranging from − 82 to − 74% Δ medians) followed by GLI1 R/G site (− 27% Δ medians), the latter playing a key role in modulating the Hedgehog (HH) signaling in cancer [35]. The gene discussed is GRIK2; the disease is cancer.