Since then, more studies on LRG-1 have emerged gradually and LRG-1 is recognized as a new regulator of tumorigenesis and a novel oncogene-associated protein [15, 16], playing an important role in epithelial-mesenchymal transition (EMT) and angiogenesis in colon cancer [16, 17]. The gene discussed is LRG1; the disease is malignant colon neoplasm.