The hub-genes of LRRK2, CALM1, CXCR4, TLR4, CTNNB1, CXCR2, KIT, and IL1B may be associated with AF recurrence and maintenance and CD19, FGF9, SOX9, GNGT1, and NOG may be associated with stroke. The gene discussed is CXCR2; the disease is Stroke.