Similarly, cyclo(L-Pro-L-Phe) (11) isolated from Bacillus species also caused apoptosis in U-87MG cells from human glioblastoma through AKT1 inactivation by down-regulating the phosphorylation of AKT1 serine/theorine kinase at 0.01 mg/mL [95, 99]. Here, AKT1 is linked to glioblastoma.