Mean±SD IGF1/IGFBP3 molar ratio on rGH treatment was 0.19±0.07 (range: 0.12-0.35) for the SGA group, 0.20±0.08 (range 0.04-0.36) for the GHD group and 0.19±0.09 (range: 0.04-0.32) for the PWS group (Figure 1B). This evidence concerns the gene IGF1 and Prader-Willi syndrome.