KDM4B and obesity due to melanocortin 4 receptor deficiency: Although there were some differences between the respective models, knocking out Kdm4b in adipose tissue generally resulted in increased obesity, with increased expression of adipogenesis genes (e.g., Pparg2 and aP2) and reduced expression of genes in energy expenditure and lipolysis pathways (e.g., Ppargca1, Ppara, Acox1, and Atgl) [71,72].