SASH3 and hyperinsulinemic hypoglycemia, familial, 4: The rescue of SLY expression was also examined in mice with severe NPYq deficiency (9/10NPYq-) with (tsgic) and without (neg sib) Flag-Sly transgene addition, with a distinction between cytoplasmic and nuclear SLY expression to assess the transgenic SLY ability to mimic the behavior of endogenous SLY (Figure 3E).