Another study demonstrated that EGFR synergizes with GLI in the carcinogenesis process via the RAS/RAF/MEK/ERK axis and that in vitro dual inhibition of epidermal growth factor receptor (EGFR) and GLI led to a more potent reduction in cell proliferation in BCC cells than either inhibitor alone [25]. The gene discussed is EGFR; the disease is skin basal cell carcinoma.