In addition, the results of the “single-SNP” and “leave-one-out” methods showed that rs1175550 in the SMIM1 gene significantly affected the correlation of Cu with AD (Supplementary Figure S6); rs4072037 in the MUC1 gene and rs2769264 in the SELENBP1 gene, respectively, showed significant effects on the correlation of Mg and Cu with BD (Supplementary Figures S7 and S8). Here, SMIM1 is linked to Behcet disease.