SMIM1 and Alzheimer disease: In addition, the results of the “single-SNP” and “leave-one-out” methods showed that rs1175550 in the SMIM1 gene significantly affected the correlation of Cu with AD (Supplementary Figure S6); rs4072037 in the MUC1 gene and rs2769264 in the SELENBP1 gene, respectively, showed significant effects on the correlation of Mg and Cu with BD (Supplementary Figures S7 and S8).