Hesperidin consumption also can be effective on PD models via down-regulating the level of proinflammatory cytokines such as TNF-α, IL-1β, IL-6, IL-4, and IL-10, as well as affecting glial fibrillary acidic protein (GFAP), iNOS, and COX-2 levels [81]. Here, GFAP is linked to Parkinson disease.