CCL2 and infection: Various chemokine genes, responsible for the control and recruitment of immune cells to the site of infection (i.e., Ccl2, Ccl4, Ccl5, Ccl7, Ccl8, Ccl12, and Ccl19), were also significantly upregulated in the VACV-Wyeth infected brains on 4 d.p.i (Table 3).