The carboxyl group engages a network of stable H-bond interactions with PPARα-Tyr464 (MD occurrence >60%)/PPARγ-Tyr473(H12) (MD occurrence >90%), PPARα-His440 (MD occurrence >55%)/PPARγ-His449(H10/11) (MD occurrence >38%), PPARα-Tyr314 (MD occurrence >80%)/PPARγ-His323(H5) (MD occurrence >55%), and PPARα-Ser280(MD occurrence >11%)/PPARγ-Ser289(H3) (MD occurrence >21%). This evidence concerns the gene PPARA and Menkes disease.