However, in a second study published later in 2016 [75], the same group showed that together with the decrease of FoxO1 expression in the four-week period of CTEPH development, anti-apoptotic Bcl-2 also decreased, while pro-apoptotic Bad levels were increased in the PAECs. The gene discussed is FOXO1; the disease is chronic thromboembolic pulmonary hypertension.