An anomalous histone acetylation, and consequently an alteration in the expression of HDACs, is related to cancer [34,35,36,37,38,39] Likewise, an overexpression of HDAC1 and HDAC2 has been found in LC [40], and HDAC8 knockdown leads to the inhibition of cell proliferation in lung and other types of cancer [41]. Here, HDAC8 is linked to cancer.