BDNF and retinal degeneration: Moreover, the successful transplantation of genetically engineered MSCs secreting BDNF in the central nervous system (CNS) was already performed in axotomized retina and in laser induced injury [22,23]; however, to our knowledge, there are no studies that have specifically analyzed the effect of the continuous delivery of BDNF via combined cellular and gene-based therapy in a model of chronic retinal degeneration.