Among the various aberrantly spliced TSG101 mRNAs, an isoform missing internal 901 nucleotides (termed TSG101∆154-1054 or TSG101∆190-1090, which lacks residues 204 to 1104 according to the latest RefSeq NM_006292.3) is predominant in most tumor tissues [17,18,19,21,24]. This evidence concerns the gene TSG101 and neoplasm.