Notably, we found that SEMA3C is a secreted, soluble autocrine growth factor in PCa and importantly combined with our findings that SEMA3C is transcriptionally regulated by AR in a GATA-binding protein 2 (GATA2)-dependent manner [78], these data collectively make SEMA3C the first bona fide PCa-derived andromedin to be identified. Here, AR is linked to posterior cortical atrophy.