Surprisingly, over the two-year study period, a height gain of only 0.3 standard deviation scores (SDS) was observed in children with GHD and T1DM indicating decreased efficacy of GH treatment in children with T1DM, but no data on GH dosage and IGF-I concentrations was available in the database [6]. The gene discussed is IGF1; the disease is type 1 diabetes mellitus.