Children with well-controlled T1DM and GHD suggesting growth pattern should undergo regular “short stature work-up” even though diagnosis of GHD might be challenging in children with T1DM because of the disturbed GH–IGF-I axis with hepatic GH resistance, GH hypersecretion, and low circulating IGF-I [8,9,10]. This evidence concerns the gene GH1 and type 1 diabetes mellitus.