Infection of ZF with Mabs is characterized by (1) rapid engulfment of the bacilli by macrophages; (2) activation of macrophages, resulting in chemotaxis guiding neutrophils to pre-forming granulomas and ROS production by NOX2 for intracellular killing of Mabs; and (3) homeostatic granuloma formation to sequester Mabs, containing the infection and favoring the development of chronic disease. Here, CYBB is linked to infection.