However, although the altered NADPH oxidase function in CGD can lead to increased disease severity following infection with M. tuberculosis or vaccination with M. bovis BCG (Deffert et al., 2014), reports of infection with NTM remain anecdotal (Ohga et al., 1997; Weening et al., 2000; Chusid et al., 1975), and no particular link with M. abscessus has been ascribed yet. Here, FMO5 is linked to chronic granulomatous disease.