To investigate whether distantly related members of the Flaviviridae family rely on MARCH8, we examined the effect of MARCH8 gene silencing on infection with the luciferase reporter DENV2 New Guinea C (NGC) strain (Xie et al., 2013; Zou et al., 2011) and ZIKV (Asian strain; Shan et al., 2016). This evidence concerns the gene MARCHF8 and infection.